There are lots of motorcycle "bucket list rides" in Appalachia, especially the Blue Ridge province. As a matter of fact Motorcycle Roads website ranks 30 of the top 100 motorcycling roads in America in the region.
I've been traveling the Appalachian Mountains all of my life, first in the family station wagon, then on my motorcycle. It's gorgeous country, and the people who call it home are often misunderstood. I know this because they are my people.